Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina

doi:10.1186/1754-6834-2-19

Biotechnology for Biofuels

Volume 2

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Kubicek CP
Mikus M
Schuster A
Schmoll M
Seiboth B

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Mikus M
Schuster A
Schmoll M
Seiboth B
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This article is part of a series on The Life and Lifework of Mary Mandels - First Lady of Cellulase Research, edited by Prof Edward A Bayer.

Review

Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina

Christian P Kubicek , Marianna Mikus , André Schuster , Monika Schmoll and Bernhard Seiboth

Research Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, TU Vienna, Getreidemarkt, A-1060 Vienna, Austria

author email corresponding author email

Biotechnology for Biofuels 2009, 2:19doi:10.1186/1754-6834-2-19


Published:	1 September 2009

Abstract

Hypocrea jecorina (= Trichoderma reesei) is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering.